CBD Suppositories for Adenomyosis Relief

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What does the latest clinical research say about the effectiveness of CBD as a relief for Adenomyosis?


All available studies focus on endometriosis and the potential therapeutic benefits of CBD on various aspects of the condition. However, these findings may also have implications for adenomyosis, as it is a similar condition involving abnormal growth of endometrial-like tissue.


One study published in the journal Cannabis and Cannabinoid Research in 2017 investigated the effects of CBD and THC on endometriosis-related pain and inflammation in a mouse model. The study found significant reductions in pain and inflammation with CBD and THC treatment compared to placebo, suggesting potential benefits for individuals with endometriosis.


In another study published in the Journal of Clinical Investigation in 2020 scientists looked at how the body's endocannabinoid system might be involved in causing endometriosis. They found that when this system is not working properly, it might cause endometriosis to get worse. This suggests that using treatments based on cannabinoids (CBD) could be a new way to treat endometriosis.

What is Adenomyosis?

Adenomyosis is a condition characterized by the presence of endometrial tissue, which normally lines the uterus, growing into the muscular wall of the uterus, known as the myometrium. This can cause the uterus to become enlarged, resulting in various symptoms such as pelvic pain and heavy menstrual bleeding.


Understanding the Anatomy of the Uterus: The uterus consists of three layers: the outermost layer (perimetrium), the middle muscular layer (myometrium), and the inner lining (endometrium). In adenomyosis, the endometrial tissue infiltrates into the myometrium, leading to the characteristic features of the condition.


Differentiating Adenomyosis from Other Gynecological Conditions: Adenomyosis shares some similarities with other gynecological conditions such as endometriosis and uterine fibroids. However, it is distinct in terms of its pathophysiology and location of tissue involvement within the uterus.

What Are The Symptoms of Adenomyosis?

  • Menstrual Pain and Heavy Bleeding: Also having intense cramps before bleeding and during. Experiencing an extended bleed window, and a heavy flow that is irregular month to month.
  • Pelvic Discomfort and Pressure: A feeling of fullness or heaviness in the pelvic region, lower abdomen, and lower back area. Before and During Bleed window. This discomfort can worsen during exercise or prolonged periods of standing.
  • Fertility: While adenomyosis is not always associated with infertility, it may increase the risk of miscarriage or pregnancy complications.

What Are The Causes of Adenomyosis?

The cause of adenomyosis remains a mystery to doctors, which is unhelpful. But there are 'potential' factors that are being considered:


  • High levels of estrogen to progesterone, could have an effect on the growth and thickness of the endometrial tissues within the urine wall.
  • It may be hereditary, as those with the condition often share it with their relatives.
  • Could be connected to endometriosis, which is a similar condition where endometrial cells are present outside the uterus. In some individuals, both conditions are present.

What Do We Get Wrong About the Causes of Adenomyosis?

Debunking Myths:

Contrary to urban legend, turning upside down, doing yoga, or engaging in vigorous exercise does not cause adenomyosis. Even though studies are limited, we do know it is primarily hormonal or genetic rather than lifestyle choices or physical activities.


Environmental and Lifestyle Factors:

There is not enough research to suggest that exposure to endocrine-disrupting chemicals, lifestyle habits, bad diet, or stress have an impact. This requires much further research and less speculation. 


How is Adenomyosis Treated?

There is no cure other than stopping menstruation entirely, which is not possible for individuals seeking to maintain fertility. However, below, we list the current treatments.


Medications for Pain Management and Hormonal Regulation:

Anti-inflammatories, hormones, and contraceptives could help with menstrual pain and heavy bleeding. These have the potential to reduce estrogen, thereby controlling the growth of endometrial tissue. But this is not a cure.


Hysterectomy and Endometrial Scraping: These are severe cases only, but a hysterectomy (removal of the uterus) or endometrial scraping (removal and or destruction of the uterine lining).

Can CBD Suppositories Offer Adenomyosis Relief?

CBD interacts with the endocannabinoid system, which manages pain perception, inflammation, and hormonal regulation. So taking CBD suppositories about five days before you bleed and consistently during could help with pain and inflammation associated with adenomyosis.


CBD suppositories offer a direct hit to the lower body abdomen and pelvic area. The blood vessels in the bottom or vagina allow for direct absorption into the bloodstream, bypassing the digestive system and potentially enhancing therapeutic effects. 

CBD Suppositories for Adenomyosis Relief

Can CBD Suppositories Upset Healthy Endometrial Cells?

No, there is no evidence to suggest that CBD suppositories have adverse effects on healthy endometrial cells.


However, there is research to suggest that CBD can stop unhealthy endometrial cells from misbehaving. In particular, CBD can stop the endometrial cells from migrating to other areas of the body.


Before using CBD suppositories, it's advisable to consult with a healthcare professional, particularly if you have any underlying health conditions or are taking medications. Additionally, if you experience any adverse effects while using CBD suppositories, it's essential to discontinue use and seek medical advice. Further research is needed to fully understand the potential effects of CBD suppositories on endometrial cells.

Are CBD Suppositories Safe to Use With Medications?

CBD Suppositories are considered safe to use with other medications or sexual health products.


BUT, it is important to talk to your healthcare provider before using CBD or any other supplement, especially if you are taking medications or have any underlying health conditions. CBD can interact with certain medications, such as blood thinners, and may increase or decrease their effects. 

What are the Holistic Tips to Manage Adenomyosis?

If you are looking for a holistic approach to try, we list them below. We recommend starting these during the follicular phase of your period, the week directly after your period. You will be in a better mood, experience less pain, and be ready to successfully implement diet or lifestyle changes.


This condition is no joke, so if you are in deep discomfort, and currently on your period, please do what you need to do to nurture and support yourself. Chill, rest, binge, relax and recover. Smoke your Jay, and think about tackling these once you are on the other side.


Holistic Approaches:

  1. Strengthening the muscles of the pelvic floor through regular kegal practices could reduce the severity of the pain.
  2. Manual therapy, massage, or pelvic floor relaxation by a physiotherapist could help manage the discomfort.
  3. Consuming a daily dose of sunflower, pumpkin, flax, and sesame seeds could assist with hormone regulation.
  4. Yoga, meditation, deep breathing exercises, and progressive muscle relaxation can help manage the emotional toil on your body.
  5. Adequate hydration and rest

At Mello, We highly recommend considering CBD suppositories as a potential option for managing symptoms associated with adenomyosis due to their potential therapeutic benefits in alleviating pain and inflammation. There are also research studies suggesting CBD may prevent endometrial cells from multiplying, which could have the potential to be a long term solution for sufferers. 

What To Avoid:

These have been shown to exacerbate hormonal imbalances and so could be a trigger for adenomyosis symptoms:


  • Binge drinking
  • More than 2 cups of caffeine
  • Processed meats
  • Pharmaceutical mood enhancers